N-Moc-MDMA: A Detailed Overview
Introduction to N-Moc-MDMA
N-Moc-MDMA, or N-(4-methoxycarbonylphenyl)-3,4-methylenedioxy-N-methylamphetamine, is a modified derivative of MDMA (3,4-methylenedioxy-N-methylamphetamine). MDMA is widely known for its psychoactive properties and its use in therapeutic contexts like the treatment of PTSD and anxiety. N-Moc-MDMA has similar structural features to MDMA but includes an additional moiety—an N-(4-methoxycarbonylphenyl) group. This modification alters its chemical, pharmacological, and metabolic characteristics, providing researchers with a valuable compound for studying MDMA-like substances and their effects.
This article will provide an in-depth analysis of N-Moc-MDMA, including its chemical structure, synthesis, pharmacological properties, applications, and where to buy N-Moc-MDMA in various regions such as Australia, the UK, Europe, and the USA.
Chemical Structure and Properties of N-Moc-MDMA
Molecular Structure
The molecular formula of N-Moc-MDMA is C16H19NO3. Like MDMA, it contains a methylenedioxy group attached to a benzene ring, as well as a methylated amine side chain. However, N-Moc-MDMA introduces a methoxycarbonyl group (–COOCH3) at the nitrogen atom in place of the standard amine group seen in MDMA. This substitution is key to its distinct characteristics, and it provides a functional group that influences the compound’s chemical reactivity, solubility, and interaction with biological systems.
Functional Group: Methoxycarbonyl
The methoxycarbonyl group at the nitrogen position of N-Moc-MDMA can significantly affect its interaction with metabolic enzymes and receptors. This group is often used in medicinal chemistry to influence a compound’s bioavailability and pharmacodynamics. The addition of this ester group may alter the compound’s ability to cross the blood-brain barrier, its affinity for serotonin, dopamine, and norepinephrine receptors, and its overall pharmacokinetics.
Synthesis of N-Moc-MDMA
The synthesis of N-Moc-MDMA is a multi-step process that involves introducing the methoxycarbonyl group at the nitrogen atom in the MDMA molecule. Below is a simplified overview of the typical synthetic pathway:
1. Preparation of MDMA Derivative
The synthesis begins with the preparation of a precursor molecule based on MDMA, which contains the essential methylenedioxy group and the ethylamine side chain. Starting with MDMA or a closely related compound is crucial for maintaining the structural framework required for the psychoactive effects.
2. Introduction of the Methoxycarbonyl Group
The next step involves the introduction of the methoxycarbonyl group at the nitrogen atom. This reaction typically requires the use of reagents such as methyl chloroformate or dimethyl carbonate, which react with the amine group of MDMA to form the ester linkage. This step is carried out under controlled conditions to ensure that the methoxycarbonyl group is introduced selectively.
3. Purification and Finalization
After the esterification reaction, the product is purified to remove any unreacted reagents or byproducts. The final product, N-Moc-MDMA, is typically obtained as a crystalline or powder form, and it is often stabilized in a salt form for ease of handling in research laboratories.
Pharmacological Properties of N-Moc-MDMA
As a derivative of MDMA, N-Moc-MDMA is expected to share some pharmacological properties with its parent compound, but the addition of the methoxycarbonyl group may result in unique effects. These potential effects are crucial for researchers exploring the biochemical and pharmacological mechanisms of MDMA-like compounds.
1. Serotonergic Activity
MDMA is well known for its ability to significantly release serotonin, leading to enhanced mood, empathy, and emotional well-being. N-Moc-MDMA, due to its structural similarities to MDMA, is also likely to engage with serotonin receptors, particularly the 5-HT2A and 5-HT1A receptors. However, the introduction of the methoxycarbonyl group may modulate the potency of serotonin release or alter the receptor binding affinity compared to MDMA.
2. Dopaminergic and Noradrenergic Activity
Like MDMA, N-Moc-MDMA may also interact with dopamine and norepinephrine transporters. These interactions contribute to MDMA’s stimulant effects, such as increased alertness, energy, and heart rate. The methoxycarbonyl modification could potentially influence the compound’s efficacy in affecting dopamine and norepinephrine levels, making it a valuable compound for studying the dynamics of these neurotransmitters in the brain.
3. Potential Therapeutic Applications
The modification of MDMA with a methoxycarbonyl group opens up potential applications in the development of new therapeutic compounds. The altered pharmacokinetics and bioactivity of N-Moc-MDMA could provide new leads for the development of safer or more effective treatments for mood disorders, anxiety, and PTSD. Understanding how the methoxycarbonyl group affects receptor interactions is key for designing future drug candidates.
4. Toxicological Considerations
As with other MDMA derivatives, the toxicity of N-Moc-MDMA is an important consideration for researchers. The compound’s effects on serotonin levels, temperature regulation, and cardiovascular health must be carefully examined in preclinical studies. The methoxycarbonyl modification may reduce or increase the potential for adverse effects, and more research is required to fully understand its safety profile.
Applications of N-Moc-MDMA in Research
N-Moc-MDMA has several important applications in research, particularly in the fields of pharmacology, neuroscience, and toxicology. Below are some of the primary uses for this compound:
1. Investigation of MDMA Metabolism
N-Moc-MDMA is a valuable tool for studying the metabolism of MDMA and its derivatives. By comparing the metabolic pathways of MDMA and N-Moc-MDMA, researchers can explore how the methoxycarbonyl group affects the compound’s breakdown in the body. This information is crucial for understanding the long-term effects of MDMA-based drugs and optimizing their therapeutic use.
2. Study of Serotonergic Systems
Researchers studying serotonin systems in the brain can use N-Moc-MDMA to investigate how structural changes in MDMA affect its interaction with serotonin receptors. By examining how N-Moc-MDMA binds to and activates serotonin receptors, scientists can gain insights into the mechanisms that underlie mood regulation, empathy, and other behavioral effects.
3. Neurotoxicity and Safety Assessment
N-Moc-MDMA serves as a useful compound for neurotoxicity studies, allowing researchers to assess whether the methoxycarbonyl modification alters the compound’s potential for neurotoxicity compared to MDMA. Investigating its safety profile is critical for determining whether it could have clinical applications in humans.
4. Development of Novel Therapeutics
Given the structural similarities between N-Moc-MDMA and MDMA, this compound may serve as a precursor for the development of novel therapeutic agents targeting mood disorders, anxiety, and PTSD. The modification introduced by the methoxycarbonyl group could provide a foundation for designing drugs with improved efficacy or reduced side effects.
Where to Buy N-Moc-MDMA
For researchers and institutions interested in acquiring N-Moc-MDMA for scientific studies, several reputable chemical suppliers offer this compound. Below are some options for purchasing N-Moc-MDMA in various regions:
Buy N-Moc-MDMA in Australia
In Australia, N-Moc-MDMA can be purchased from scientific supply companies that specialize in research chemicals. These suppliers typically offer products in high purity for academic and pharmaceutical research purposes.
Buy N-Moc-MDMA in the UK
UK-based researchers can buy N-Moc-MDMA from chemical distributors who supply a range of MDMA derivatives for laboratory use. These suppliers ensure that the compound meets stringent quality control standards suitable for scientific applications.
Buy N-Moc-MDMA in Europe
Across Europe, there are several chemical suppliers that offer N-Moc-MDMA. Countries like Germany, the Netherlands, and France are home to distributors that can provide the compound for research purposes, with options for international shipping.
Buy N-Moc-MDMA in the USA
In the USA, N-Moc-MDMA is available from several well-established chemical supply companies. Institutions and researchers can find reliable sources for high-quality research chemicals, ensuring the product is suitable for their scientific investigations.
For additional information on acquiring N-Moc-MDMA, you may consider visiting reputable suppliers such as Sigma-Aldrich and Fisher Scientific.
Safety and Handling of N-Moc-MDMA
Working with N-Moc-MDMA requires careful handling to ensure safety and maintain the integrity of the compound. Researchers must adhere to proper laboratory protocols when handling this compound.
1. Personal Protective Equipment (PPE)
Researchers should wear appropriate PPE, including gloves, goggles, and lab coats, to minimize exposure to chemicals. It is important to avoid inhaling or ingesting any chemical substances.
2. Proper Storage Conditions
N-Moc-MDMA should be stored in a cool, dry place, away from heat sources and direct sunlight. It should be kept in tightly sealed containers to prevent contamination and ensure stability.
3. Disposal Procedures
Proper disposal of N-Moc-MDMA should follow local environmental and chemical waste disposal regulations. Unused compounds and waste should be disposed of in designated chemical waste containers to minimize environmental impact.
Conclusion
N-Moc-MDMA is an important derivative of MDMA that offers researchers a unique tool for studying the pharmacology, metabolism
, and safety of MDMA-based compounds. Its distinctive chemical structure, including the methoxycarbonyl modification, opens the door to a variety of potential applications in neuroscience, pharmacology, and drug development. With careful research and study, N-Moc-MDMA could contribute significantly to the understanding of MDMA-like substances and their therapeutic potential.
If you are interested in purchasing N-Moc-MDMA for research purposes, be sure to source the compound from reputable suppliers in regions such as Australia, the UK, Europe, and the USA.
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