N,N-Diformylmescaline: Overview and Detailed Insight

N,N-Diformylmescaline is a unique compound that has attracted attention within the scientific and psychedelic communities. It is a derivative of mescaline, a naturally occurring psychoactive compound known for its hallucinogenic effects. Understanding N,N-Diformylmescaline requires delving into its chemical structure, synthesis, potential effects, and its legal status across various regions, including the USA, Europe, Australia, and the UK.

Abstract

N,N-Diformylmescaline, a novel analogue of mescaline, has recently been detected in Australia in two unrelated seizures. To confirm the identification, a three-step synthesis from 3,4,5-trimethoxyphenylacetic acid was devised. However, purification of the final product proved problematic with the compound prone to degradation in solution. Analysis of the compound by LC–MS indicated that the compound was unstable under acidic and basic conditions, breaking down to N-formylmescaline. Further degradation to mescaline was observed when the compound was dissolved in hydrochloric acid for an extended period of time suggesting that N,N-diformylmescaline may be a prodrug for mescaline. The GC–MS, NMR and FTIR data for the seized compound are presented along with details of the synthesis and studies of the compound’s stability in solution.

1. Introduction

N,N-Diformylmescaline is a chemical compound that belongs to the family of phenethylamines, which includes various psychoactive substances, such as mescaline. It is a modified form of mescaline, where two formyl groups are added to the molecule, leading to its distinct properties. This derivative is part of a broader group of compounds that researchers have synthesized in an effort to better understand the neurochemical interactions that lead to hallucinogenic effects.

Although N,N-Diformylmescaline itself does not have the same level of recognition as mescaline, its unique chemical properties make it an intriguing subject for research in neurochemistry and psychedelics.

2. Chemical Structure and Synthesis

Mescaline: The Parent Compound

Before diving into N,N-Diformylmescaline’s specific synthesis and structure, it is essential to understand its parent compound, mescaline. Mescaline (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic alkaloid found in various cacti, including Peyote, San Pedro, and the Peruvian torch cactus. It is well-known for inducing vivid visual and auditory hallucinations, as well as intense shifts in perception and consciousness. Mescaline’s chemical properties and its impact on the brain have been widely studied in the context of its therapeutic potential.

Synthesis of N,N-Diformylmescaline

N,N-Diformylmescaline is synthesized by modifying the mescaline molecule. The modification involves introducing two formyl groups (-CHO) at the nitrogen positions of the mescaline molecule. This process typically involves a series of chemical reactions starting from mescaline, where specific reagents are used to add the formyl groups to the structure. The result is a compound with altered characteristics, which may influence its interaction with the brain’s serotonin receptors, leading to potential variations in psychoactive effects.

The synthesis of N,N-Diformylmescaline is primarily of interest within the scientific community, as it offers insights into the chemistry of psychedelic compounds and their potential therapeutic uses. Researchers focus on how small structural changes in psychoactive molecules can impact their pharmacology and safety profile.

3. Mechanism of Action

Like mescaline, N,N-Diformylmescaline likely exerts its effects by interacting with serotonin receptors in the brain, particularly the 5-HT2A receptor. The 5-HT2A receptor is crucial for regulating mood, perception, and cognition. By binding to these receptors, It may alter sensory perception, emotional state, and cognitive processing, leading to psychedelic effects.

However, the exact mechanism of N,N-Diformylmescaline remains less studied than its parent compound, mescaline. It is assumed that the formyl groups attached to the mescaline molecule may influence the compound’s affinity for serotonin receptors and potentially alter its potency, duration of action, and side-effect profile compared to mescaline.

How does works

N,N-Diformylmescaline works primarily by interacting with the brain’s serotonin receptors, similar to its parent compound, mescaline. Specifically, it is believed to affect the 5-HT2A receptors, which play a key role in regulating mood, cognition, and perception.

When N,N-Diformylmescaline binds to these receptors, it can induce changes in sensory perception, mood, and consciousness, resulting in the psychedelic effects that are characteristic of mescaline-like substances. These effects can include vivid visual and auditory hallucinations, changes in the perception of time, altered thought processes, and intense emotional experiences.

The key difference between N,N-Diformylmescaline and mescaline is its chemical modification—the addition of two formyl groups to the mescaline molecule. This modification could influence the compound’s binding affinity to serotonin receptors, potentially affecting the intensity, duration, and nature of its psychoactive effects. While the exact mechanism is not fully understood, these subtle chemical differences could lead to slightly altered effects compared to mescaline itself.

In essence, N,N-Diformylmescaline works by altering neurotransmitter signaling, particularly through serotonin pathways, which results in the distinct changes in perception, thought, and consciousness that are typically experienced with psychedelic substances.

4. Effects and Potential Uses

Psychoactive Effects

When consumed, N,N-Diformylmescaline is expected to produce effects similar to mescaline, though potentially more intense or subtle depending on the individual. Users may experience visual and auditory hallucinations, alterations in perception of time, enhanced emotional sensitivity, and an altered sense of reality. These effects can be both profound and introspective, with some users reporting enhanced creativity or a sense of connection with nature or the universe.

The psychoactive effects of N,N-Diformylmescaline could vary widely from person to person, depending on factors such as dosage, individual neurochemistry, and setting. Given its structural similarity to mescaline, it is likely that Diformylmescaline’s effects will share similarities but may also have distinct differences.

Therapeutic and Research Implications

The psychoactive properties of N,N-Diformylmescaline, along with its relationship to mescaline, suggest that it could have therapeutic potential, especially in the realm of mental health and psychedelic research. Psychedelic compounds have been shown to offer therapeutic benefits for conditions such as depression, anxiety, and PTSD in controlled settings. As a derivative of mescaline, N,N-Diformylmescaline may share these therapeutic properties, although more research is needed to confirm its efficacy and safety.

Furthermore, the compound could serve as a useful tool for researchers looking to study the psychoactive effects of altered mescaline derivatives, potentially offering deeper insights into the mechanisms of action of psychedelics.

5. Legal Status of N,N-Diformylmescaline

Legal Status in the USA

The legal status of N,N-Diformylmescaline in the United States is largely unclear, as it is a relatively obscure compound. Mescaline itself is a Schedule I controlled substance under the Controlled Substances Act, making it illegal to manufacture, possess, or distribute. Since it is a derivative of mescaline, it may be subject to similar legal restrictions, especially if it is classified as a controlled substance analog.

However, because it is not explicitly listed in the Controlled Substances Act, which could leave a gray area regarding its legality, individuals interested in buying N,N-Diformylmescaline in the USA should be aware of potential legal risks and ensure they understand current drug laws before acquiring such substances.

Legal Status in Europe

The legal situation for N,N-Diformylmescaline in Europe is similarly complicated. Mescaline is illegal in many European countries, often classified as a controlled substance under national drug laws. Given that N,N-Diformylmescaline is a derivative of mescaline, it is possible that it could be subject to similar legal restrictions across European nations.

Some European countries may have more specific laws addressing analog substances, which could impact the legality of N,N-Diformylmescaline. As with the USA, it is crucial for individuals considering the purchase of N,N-Diformylmescaline in Europe to check local regulations and seek legal advice if needed.

Legal Status in Australia

In Australia, the legal status of N,N-Diformylmescaline is highly regulated due to its relation to mescaline, which is classified as a Schedule 9 substance under the Australian Poisons Standard. This makes the manufacture, possession, and supply of mescaline illegal in Australia. Given that N,N-Diformylmescaline is a derivative of mescaline, it is likely that this compound would also be subject to strict legal controls. Individuals considering the purchase of N,N-Diformylmescaline in Australia should ensure they are fully informed about local drug laws and the potential legal implications.

Legal Status in the UK

In the UK, mescaline is classified as a Class A controlled drug under the Misuse of Drugs Act. As a derivative of mescaline, N,N-Diformylmescaline may fall under the same legal restrictions. The UK’s Psychoactive Substances Act 2016 also criminalizes the production and supply of any substance that could be used for psychoactive purposes, which could include N,N-Diformylmescaline. Anyone interested in buying N,N-Diformylmescaline in the UK should proceed with caution and verify the legality of such substances under UK law.

6. Buying N,N-Diformylmescaline: Considerations

Buy N,N-Diformylmescaline in USA

If you’re considering buying N,N-Diformylmescaline in the USA, it is essential to exercise caution. While the compound is not explicitly listed as a controlled substance, it may still fall under analog drug laws, which could classify it as illegal. It is critical to ensure that you are aware of the legal risks involved before attempting to purchase or possess N,N-Diformylmescaline in the USA.

Online marketplaces may claim to sell N,N-Diformylmescaline, but these offerings should be approached with caution. Many of these substances could be unsafe, adulterated, or illegal to possess. Always consider the legal and safety risks involved, and ensure you are well-informed before proceeding.

Buy N,N-Diformylmescaline in Europe

Similarly, purchasing N,N-Diformylmescaline in Europe carries legal and safety considerations. The legal status of mescaline and its derivatives varies across European countries, and individuals interested in obtaining the compound should be aware of the local drug laws. It is advisable to proceed with caution and seek expert legal counsel if considering the purchase of N,N-Diformylmescaline in Europe.

Buy N,N-Diformylmescaline in Australia

When considering the option to buy N,N-Diformylmescaline in Australia, the legal and safety concerns should not be overlooked. Since mescaline and its derivatives are controlled substances in Australia, obtaining N,N-Diformylmescaline could have serious legal consequences. Individuals interested in acquiring such compounds should take careful precautions and consult legal experts to understand the risks involved.

Buy N,N-Diformylmescaline in UK

In the UK, as mescaline is classified as a Class A controlled substance, any derivative, including N,N-Diformylmescaline, is likely to face similar legal restrictions. Anyone considering the purchase of N,N-Diformylmescaline in the UK must fully understand the legal framework governing controlled substances and the potential consequences of possessing or distributing such compounds.

7. Risks and Safety Considerations

As with any psychoactive substance, the use of Diformylmescaline carries inherent risks. The effects of the compound can be unpredictable, especially in higher doses, and could lead to undesirable psychological or physiological outcomes. There may be risks of exacerbating underlying mental health conditions, particularly for individuals with a history of psychosis or other psychiatric disorders.

Additionally, the purity and quality of Diformylmescaline purchased from non-regulated sources are often unknown, which could lead to contamination or the presence of harmful substances. It is essential to be cautious about where and how the compound is obtained.

8. Conclusion

N,N-Diformylmescaline is a fascinating derivative of mescaline, offering unique chemical properties and potential for future research. While it shares many similarities with its parent compound, mescaline, its specific effects, mechanisms of action, and potential therapeutic uses remain largely unexplored. As with any psychoactive substance, it is important to be aware of its legal status and the associated risks before purchasing or using N,N-Diformylmescaline.

If you are interested in buying N,N-Diformylmescaline in the USA, Europe, Australia, or the UK, it is essential to thoroughly research the legal implications and safety concerns before making any decisions. Ultimately, as research into psychedelic compounds continues to evolve, substances like Diformylmescaline may play a significant role in the future of neurochemistry and mental health treatment.